British Air Force Typhoon jets have operated alongside French aircraft in a combined operation on an subterranean weapons facility in Syria operated by the IS group, according to the British defence ministry.
The facility, located using surveillance, was assessed as containing munitions and bombs, the statement said, and was positioned in hills just above Palmyra in central Syria.
"The RAF jets used laser-guided Paveway IV weapons to strike a series of approach shafts down to the facility... initial indications are that the objective was successfully hit," officials stated.
There was no evidence of any civilian impact in the operation late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The British jets were assisted by a Voyager aerial refuelling aircraft.
Daesh - alternatively referred to as Daesh - enforced jihadist rule over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This strike shows the UK's leading role, and commitment to stand shoulder to shoulder with allied nations, to stamp out any revival of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the Defence Secretary stated.
RAF aircraft have conducted surveillance missions over Syria to "prevent any attempted comeback" of Islamic State following its routing at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I must thank every member of our armed forces participating in this operation for their professionalism and their valour," Healey said. "Including them were a great many British personnel stationed over the holidays. This operation, to take out dangerous terrorists who threaten our way of life, highlights how UK forces are prepared to act, continuously, protecting the UK domestically and influential overseas."
In December, the US military conducted what it termed a "massive strike" against IS targets in Syria, following an attack claimed the lives of two American soldiers and a civilian linguist in Palmyra.
The U.N. estimates Islamic State still maintains an estimated 5,000 to 7,000 fighters in both countries.
